S2259 Aloe-emodin

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Technical Data:
M.Wt: 270.24
Formula: C₁₅H₁₀O₅ 
Solubility: Unknown
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 481-72-1

Biological Activity of Aloe-emodin:

Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. It is an anthraquinone present in aloe latex, an exudate from the aloe plant. It was identified as a potential interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. ^[1][2][3]

References on Aloe-emodin:

[1] http://en.wikipedia.org/wiki/Aloe_emodin

[2]Pecere T et al. Cancer Res. 2000 Jun 1;60(11):2800-4.

[3]Lin CW et al. Int J Antimicrob Agents. 2008 Oct;32(4):355-9.