Anti-Human Nanog Purified ebioscience

Anti-Human Nanog Purified ebioscience

产品名称：Anti-Human Nanog Purified ebioscience
产品货号：14-5768-80
产品规格：25 ug
产品品牌:eBioscience

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Description

Description: The hNanog.2 antibody recognizes human Nanog, a homeobox transcription factor expressed in embryonic stem cells (ESC). Nanog is essential for self-renewal of ESC and the inner cell mass and is throught to function in the same capacity as other factors such as Oct4 and Sox2. Nanog plays a crucial role in embryonic cell fate specification following formation of the blastocyst by regulating proliferation and preventing differentiation. Nanog functions by directly binding DNA consensus sequences to activate or repress transcription. In differentiating ESC, Nanog binds to its own promoter leading to repression of expression. Nanog has been reported to be overexpressed in germ cell tumors of the gonads and central nervous system as well as breast and colorectal cancer.

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