TemoporfinCAS No.: 122341-38-2Formula: C44H32N4O4Molecular Weight: 680.75Biological Activity: Temoporfin is a synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size. Temoporfin(KW 2345) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.Patients can remain photosensitive for several weeks after treatment.

TAK242; TAK 242;Resatorvid; 瑞沙托维; Resatorvid(TAK-242)CAS: 243984-11-4Formula: C15H17ClFNO4S                         Molecular Weight:  361.82Biological Activity: TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling. TAK-242 is in treatment of sepsis and septic shock.TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.

Cyclopamine(11-Deoxyjervie)CAS:4449-51-8 Formula: C₂₇H₄₁NO₂                                           Molecular Weight:411.62Biological Activity:Cyclopamine is a Hedgehog (Hh) pathway antagonist with IC50 of 46 nM in the Hh cell assay.

ICG-001                                                                     CAS No.:847591-62-2Formula: C₃₃H₃₂N₄O₄                                 Molecular Weight:548.63Biological Activity:ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM.

(-)-Isocorypalmine;L-Isocorypalmine; L-Tetrahydrocolumbamine左旋异紫堇杷明碱;(-)-异延胡索单酚碱; 四氢非洲防己碱CAS: 483-34-1Formula: C20H23NO4Molecular Weight: 341.4Biological Activity:(-)-Isocorypalmine is a metabolite of the isoquinoline alkaloid biosynthesis pathway.